Things To Do
Florence
Situated in the scenic Tuscan valley, Florence woos travelers with old-world avenues leading to lovely piazzas big and small. While you're soaking up the splendor, make sure to stop by the Piazza del Duomo, where the breathtaking Santa Maria del Fiore Cathedral is located, and the romantic Ponte Vecchio, a 14th century bridge overlooking the Arno River. Once central to the Renaissance movement, Florence also offers art aficionados the opportunity to see famous pieces by Michelangelo and other iconic artists of that period. As a bonus, Florence is not too far from the Chianti wine region, which makes for a good day trip.
Siena
Siena still looks much the way it did when it rivaled Florence in importance in the 1300s. Hang out with locals, tourists and University of Siena students in the expansive Piazza del Campo, then climb the Torre del Mangia bell tower's 400-plus steps for incredible city views. Follow that up with a visit to the Romanesque-Gothic Duomo di Siena, which features striking dark and light striped columns. Don't forget to save time for Santa Maria della Scala, a former hospital for Christian pilgrims.
San Gimignano
A quaint medieval town that's popular with tourists, San Gimignano is a UNESCO World Heritage Site that once featured 65 towers built by wealthy families, though only 13 remain today. Must-see attractions include the Piazza della Cisterna, the 12th-century Duomo di San Gimignano and the Via Francigena, an ancient Christian pilgrimage route that runs through town. San Gimignano also offers various restaurants and shops, many of which fill with visitors in the afternoon when tour buses arrive.
Rome
A standard stop on many European vacation itineraries, Rome is not to be missed. Italy's capital city is a globally renowned cultural and historical powerhouse, boasting everything from ancient ruins and tranquil parks to Michelin-starred restaurants. Here, you'll find the most important relic from the Roman Empire (the Colosseum), some of Michelangelo's greatest works (in the Sistine Chapel), an 18th century Baroque-style fountain (the Trevi Fountain) and, of course, the center of Catholicism (Vatican City). Other can't-miss tourist attractions in the Eternal City include the Pantheon, the Roman Forum and St. Peter's Basilica, the world's largest church.
Venice
There are few destinations in the world that are quite like Venice. Its uniqueness can largely be attributed to the canals that run through this northern Italian city like roads, carrying water taxis and buses in addition to its fleet of famous gondolas. As such, there is a palpable bustle here that may surprise some first-timers. For a relaxing Venice vacation, seek out the smaller streets and canals away from the busy Grand Canal and St. Mark's Square. Just be sure to stroll across Rialto Bridge and tour the grand St. Mark's Basilica at least once.
Amalfi Coast
The journey to the cliffside Amalfi Coast involves heart-stopping, hairpin turns on narrow roads, but travelers agree this is part of the fun. The region covers more than 30 miles of coastline and is home to 13 colorful seaside towns, each with its own story. Positano and Amalfi are the most popular, housing numerous hotels and sights. While here, hike, relax on the beach and eat to your heart's content (there are multiple Michelin-starred restaurants along the Amalfi Coast). For something more off-the-beaten-path, set your sights on Atrani. This humble fishing village boasts medieval whitewashed architecture, winding alleys and authentic Italian charm.
Cinque Terre
Cinque Terre, located on Italy's northern Ligurian coast, is made up of five idyllic towns – Manarola, Monterosso, Vernazza, Corniglia and Riomaggiore. Manarola, the region's oldest town, boasts scenic vineyards, olive groves and a centuries-old bell tower. Meanwhile, Vernazza, often considered one of Italy's most beautiful villages, is well-known for its picture-perfect houses and grand medieval castle. The region offers an abundance of exciting activities, from boat tours and hiking to cooking classes and wine tastings. While here, don't forget to save time for exploring the cliffside trail that leads from Monterosso to Vernazza.
Lake Como
If you really want to treat yourself, Lake Como is where you want to be. Here, opulent villas and hotels line the shores and serene beaches beckon to sun seekers. You'll see sleek sailboats and speedboats coasting in the middle of the lake, which is the perfect place to admire the region's surrounding hills. Meanwhile, for a lesson in luxury, tour one of the region's grand villas; top picks among travelers include Villa Melzi d'Eril, Villa Carlotta and Villa Balbianello. Later, check out the Como Cathedral, a magnificent structure boasting Gothic, Renaissance, Romanesque and Baroque elements.
Lake Garda
Located about 30 miles from Verona, Lake Garda tends to be more approachable and wallet-friendly (if a bit more touristy) than Lake Como. Activities in this recreational hot spot include swimming and windsurfing, as well as hiking and taking a funicular to Mount Baldo. Lake Garda also attracts families with Gardaland Resort, which includes themed hotels as well as an amusement park, water park and aquarium. If you're looking to get away from the crowds, go beyond the main tourist sites to the quieter northern side of the lake, where you'll find the highest mountains and tucked-away towns.