—Visit the Historic Center (Centro Histórico) —Explore the stunning Guadalajara Cathedral, Plaza de Armas, and nearby colonial architecture. —Wander Through Tlaquepaque A charming artsy neighborhood known for local crafts, galleries, live mariachi, and great restaurants. —Explore the Hospicio Cabañas A UNESCO World Heritage Site featuring powerful murals by José Clemente Orozco. —Take a Day Trip to Tequila Tour world-famous tequila distilleries like Jose Cuervo and Casa Sauza in the town where tequila was born.