If you're spending the weekend in Buffalo, it's definitely worth a trip to East Aurora (a super cute suburb) to try the beef on weck (the other food Buffalo is famous for) at this place.
If you're looking for the best wings in Buffalo, I'd go to Duff's but if you're looking for the BIRTHPLACE of wings, this is the spot.
If you're looking for something a little funkier we highly recommend Dobutsu -- think Asian fusion and delicious cocktails!
If you're coming all the way to Buffalo you'd be remiss to not visit Niagara Falls. Just a short jaunt from downtown Buffalo, and an amazing site to see!