Flight
The Pittsburgh airport is about 30 minutes from downtown Pittsburgh. There is a public transit route that you can take from the airport to downtown, as well as a list of other rental car, taxi, and shuttle options, including hotels that offer courtesy shuttle service to and from the airport. If you're planning to take an Uber or Lyft from the airport to your accomodations, you can have them pick you up at Baggage Claim Door #4 at the Commercial Arrivals Curb.
Travel Note
The venue is in the North Shore neighborhood in Pittsburgh (you can type in Heinz field to find accomodations nearby), but there are also plenty of attractions throughout Pittsburgh if you'd like to stay in a hotel nearer to them. Good neighborhoods to stay in would be Squirrel Hill or Oakland (close to the University of Pittsburgh campus, Phipps Conservatory, and Carneggie Museum of Art).
Hotel
This link has specially negotiated group hotel rates for our wedding.