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Flight
If you want to land right in Portland, there is an airport about 15 minutes from downtown (several major airlines fly here). No need for a rental car - you can Uber, Lyft or use public transit (bus) to get to your accommodations.
Flight
More flight options to Boston and about 1.5 hour drive to Portland. Plenty of rental car options or can utilize a charter bus (direct buses run hourly for around $35)
Train
Direct Bus transport from Boston Airport to Portland. No stops, leather seats and plays a movie! We use this line frequently.
House Or Rental
There are several Airbnbs and VRBOs in the area.
Hotel
Additional hotel options to review.