Flight
San Jose Airport is the closest to Santa Cruz. It's a 45 minute drive in along Highway 880 and Highway 17. Note that Highway 17 is pretty winding - have your motion-sickness-prone passengers sit in the front.
Flight
Farther north than San Jose airport. About an hour to an hour and a half drive down to Santa Cruz. No nice views along this route, unfortunately.
Flight
About as far as Oakland Airport from Santa Cruz. If you have time and are renting a car, driving down to Santa Cruz along the coast on Highway 1 is pretty spectacular. It's about an hour and a half drive through Half Moon Bay and Pescadero.
Hotel
Hotel
Hotel
House Or Rental
There are plenty of AirBnB rentals in Santa Cruz that are comparable in price to the 3-star hotels in the area.