You can't go wrong with a bourbon tasting or tour in Louisville, and many of the distilleries are concentrated on this stretch of Main Street, including Angel's Envy, Old Forester, and Evan Williams. You're also close to new craft distilleries like Copper & Kings. Read more about Louisville's Urban Bourbon scene here: https://www.bourboncountry.com/things-to-do/urban-bourbon-distilleries/
Stretching along the Ohio River and accessible from downtown, this is a great place to run or walk, and the newish Big Four Bridge is a pedestrian-only, converted railway bridge that will take you over to Indiana (though really you should just turn around and come back).