Flight
This is the closest airport. We fly Allegiant Airlines from Fort Lauderdale to Lexington (it usually flies out Thursday and Sunday). There is also the Cincinnati/Northern Kentucky International Airport or the Louisville International Airport (these are bigger airports, but farther away).
Rental Car
We suggest getting a rental car. While there are Ubers in Lexington, there are none in Richmond (the location of the wedding).
Hotel
There are many hotels in Lexington, but the closest ones to the venue are the ones by exit 87 in Richmond, KY. -TownePlace Suites by Marriott Richmond -Hampton Inn Richmond -Holiday Inn Express & Suites Richmond, an IHG Hotel