Yes (and No) Sonoma, Petaluma, and Napa are within an hour to two hours away. If you would like to go Wine Tasting reach out to Marcus.
Yes, and it may be easier depending on your location. If you choose to stay in San Francisco you could book a hotel with a shuttle from SFO.
San Francisco is a great place to stay. Especially if you want to go sightseeing in San Francisco, we can recommend some great places to go.
Please do not hesitate to reach out to Marcus or Megan.