The time can vary according to traffic and the time of day, but you can expect the drive from Kolkata to take between 3 to 4 hours.
Aside from being the place Rasa grew up and loves deeply, it is also the Headquarters of the International Society for Krishna Consciousness (ISKCON). Mayapur is a Dham, or Holy Place, and the birthplace of Sri Caitanya Mahaprabhu who is worshipped as an incarnation of Lord Krishna. It is one of the two most prominent Holy Places for Gaudia Vaishnavas, the other being Vrindavan Dham the birthplace of Lord Krishna.