The Met, MoMA, Natural History Museum, Guggenheim, etc. are of course worth a visit, but this is our favorite little museum, where you can see how the early inhabitants of our neighborhood lived. Book guided tours in advance. Also has an awesome gift shop for New York souvenirs.
... or Grimaldi's, or L&B Spumoni Gardens (under construction), because Old Fulton Street (just down the road from the 1 Hotel) has become an epicenter of some of New York's best pizza (and therefore some of the world's best pizza). You may have to wait in line, but it's worth it!
A diner that's a little upscale and a little Asian-infused. The breakfast burrito, the honey butter pancakes, and the french fries are our personal favorites but nothing on this menu could disappoint (you don't earn a James Beard mention for nothing).