Flight
SGN Airport- Ho Chi Minh City is located in the South of Vietnam. This is the only international airport in HCM city. There is a non-stop direct fly from Vietnam Airlines. But other airlines with connections can be cheaper, such as: ANA, Korean air, EVA, Starlux, China Airlines. I don't recommend Philipines Airline, because they made you pick up the luggage during transit in PL.
House Or Rental
There are alot of hotel, motel, and Airbnb in Ho chi minh city. Agoda.com is a good website to book hotel in Asia. I recommend stay in the main districts, such as District 1, 3, 5 and 10. Other district 2, 4, 7, 8,9, Binh Tan are further from the popular area.