Flight
There is a local international airport in Santorini which has connections to many European countries.
Flight
Athens has the largest airport in Greece and will offer most European/US flight connections. If you arrive there, you will need to take a second local flight or a seajet to Santorini
Travel Note
Seajet is a reliable solution for water transfers across greek islands. There are several arrival and departures from the Santorini port and it is a cheap and quick solution for travel.