Hotel
This is a personal recomendation of Will's if you are able to stay in Greenville and commute to the wedding. The Westin Poinsett hotel is a historic landmark in upstate South Carolina and offers a fantastic walkability to everything downtown Greenville can offer, including the marriage celebration venue. The interior is extremely elegant and it's worthwhile just to hang out at the bar in the lobby and have a drink or two. A room should cost around $200 a night and the drive to the wedding venue is 3 hours.
Hotel
Quaint bed and breakfast with an attention to detail and service. The on-site restaurant, Saint Jacques at Burke Manor, specializes in French Cuisine and gets stellar reviews. Seems like a good way to unwind and it's about 15 minutes away from the venue by car. Stays should cost about $250 a night.
Hotel
Affordable and accesible hotel around 6 minutes from the wedding venue. Should cost around $150 a night depending on room choice and availability.