There are many options for traveling to San Luis Obispo.
San Luis Obispo Airport
Santa Barbara Airport: 1.5 hour drive
LAX Airport: 5 hour Amtrak or 3+ hour drive
Hotel
Madonna Inn
100 Madonna Road, San Luis Obispo, CA 93405
The hotel is one in a million, and each room is unique. Rooms book up quickly, so if you have your eye on one in particular, don't hesitate! There are several other hotels close by as well.