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Flight
LAX will be the cheapest for domestic flights. It is around 100 miles from Temecula and depending on the traffic gods and time of day, the drive is around an hour and 45 minutes to two and a half hours.
Flight
San Diego is closer to Temecula (60 miles) and again, depending on traffic, is around an hour to an hour and a half away from Temecula.
Flight
John Wayne is a smaller airport in Orange County that is about 70 miles away from Temecula. However, it is pricier than LAX. In conclusion, traffic will be your biggest nemesis. If you're coming from out of town, we would suggest flying in and staying near wherever you have chosen to fly into and then driving into Temecula the next morning.