There are plenty of wineries to go taste some local wines. Oregon is world famous for Pinot Noirs.
There are lots of great hikes in the area, in the Gorge or up towards Mount Hood.
You can see the famous falls on your drive from Portland to Hood River off the highway. There is an exit and a parking lot to access and get a closer look. There is also a loop hike for those looking to get some steps in:)