If you've never been to Mesa Verde before...you NEED to go! The 5th National Park created, this was the FIRST national park created to create human creations. If you can, book a ranger led tours (but you have to book them 2 weeks in advance!). Petroglyph Point Trail is a great 2.5 mile loop if you are looking for a more strenuous adventure, but you can also see all the cliff dwellings from the road. We also recommend checking out the Far View Sights, these are some of the oldest in the part and lesser visited.
Telluride is epically beautiful. The gondola is free to ride and the views are INCREDIBLE. Staying for dinner? Casey and I recommend the Wood Ear Whiskey Lounge & Noodle Bar.
The Zu is where it is AT! Casey host his monthly wine classes here and Jodi (the owner) is just wonderful. You can view (and buy) arts from local artists and listen to local music and enjoy local beer and wine. Definitely go to the Zu.
Hot springs....need we say more?