The closest airport to San Clemente is John Wayne. If you are looking for a direct flight from the East Coast, San Diego, LAX and Long Beach are also great options.
Part of San Clemente's small town charm is that it has limited hotel options. An airbnb is a great and affordable way to explore the city. Or, if you are looking for a great hotel nearby, we suggest the Marriott Laguna Cliffs Resort in Dana Point.