Highly recommend visiting the Strip District neighborhood if you have some time (especially Saturday morning). Penn Avenue between 16th St. and 30th St. is lined with a mix of old-style grocers and gourmet food shops, street stands selling produce and T-shirts, as well as bars and restaurants.
Scale Mount Washington in one of two original 1877 cable cars for an awesome view of the Pittsburgh skyline when you reach the top. Parking available across the street from the lower station at 1197 West Carson Street ($5 roundtrip ride).