Flight
This is the easiest airport to fly into. Its fairly close to Seattle and all the touristy things, but its about an hour drive to the venue (depending on traffic) Try your best to avoid rush hour traffic for your sanity, Boston traffic is nothing compared to here. Choose the Good To Go! option when using a rental car if you plan on touring the area. It's basically like our E-ZPass system in some congested car pool areas.
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If you plan on spending some time in Seattle and see the sights, this is the general area you should look :)