We definitely recommend checking out Over-the-Rhine (OTR). It's one of our favorite areas of the city and is full of restaurants, bars, coffee shops, and shopping spots. Some of our favorite spots are Abigail Street or Alcove for dinner, Somerset for drinks, and Graeter's if you're looking for a sweet treat.
If you're looking for something to do while you're in town, Findlay Market is worth checking out. It's an upscale farmer's market in the Over-the-Rhine neighborhood with lots of local food vendors, restaurants, coffee shops, and small businesses. It's a good place to grab breakfast or lunch and walk around.
Smale Riverfront Park is a nice place to walk along the Ohio River and take in views of the city. The park has walking paths, swings, fountains, and plenty of spots to sit and relax.