SLO County Airport is the closest but has limited options.
Santa Barbara is a 1.5 hour drive but is also a smaller airport.
San Jose, SFO, LAX, & Burbank are 2.5-3.5 hours away but with more flight options.
Hotel
Quality Suites Downtown San Luis Obispo
1631 Monterey Street San Luis Obispo, CA 93401
Hotel
Apple Farm Inn
2015 Monterey Street San Luis Obispo, CA 93401
Hotel
The Wayfarer San Luis Obispo, Tapestry Collection by Hilton