Grab a bite at West Side Market then go upstairs to get the best view while you eat. While you're in Ohio City stop by one of the great local breweries; check out Great Lakes Brewing Company, Market Garden Brewery, or Nano Brew.
Food: Swensons, Slyman's, Mabel's BBQ, Barrio, Sokolowski's University Inn, Townhall Dessert: Honey Hut, East Coast Custard, Sweet Moses
If you're looking for some nightlife, check out Tremont, East 4th Street, Ohio City, or the Flats.